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ocr_text: Journal of\nMedicinal\nChemistry This article is isnsed under CC-8Y 40 @ ®\nA Data-Driven Perspective on Bioisostere Evaluation: Mapping the\nBenzene Bioisostere Landscape with BioSTAR\nPol Hernindez-Llads,* Nicholas A. Meanwell, and Angela J. Russell*\n[oa Med. Chem 202568, 16921-16939 B Read Online\nACCESS! Lil Metrics & More. | Article Recommendations | @ Supporting Information\nABSTRACT: The bioisostere landscape is continually expanding, i\nwith new scaffolds emerging as alternatives in drug design, “ poet\nIncreasingly, medicinal chemists face the challenge of selecting Sy, GL\nand prioritising these bioiosteres, often relying on personal © i\na data-driven approach to analyze the bioisostere landscape, using Trg a “a 1\nsolubility, and metabolic stability. To support the findings of the POP\nanalysis, we highlight recent and particularly elegant examples of op YEE\nbenzene bioisostere applications while identifying aress where\nproviding this Perspective and associated data-mining workflow\n(BioSTAR), we aim to support more informed decision-making in bioisosteric replacement selection in drug design and inspire\nfuture innovations in bioisostere design.
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